Regulation of microtubule cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF185, NR1H2, and TOB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF185 grouped by Regulation of microtubule cytoskeleton organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF185 →	+1.845	+0.180	.009	.004	3	6
OVARY	NR1H2 →	+0.563	+0.111	.001	.004	3	5
OVARY	TOB1 →	+1.766	+0.157	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	TAS1R3 →	+0.349	+0.138	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	SPSB3 →	+1.108	+0.160	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	CDS1 →	+0.845	+0.130	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF185 by Regulation of microtubule cytoskeleton organization activity — STOMACH

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