Interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-1-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC13D, ELANE, and MMP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-1-mediated signaling pathway activity versus UNC13D in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UNC13D →	+0.635	+0.126	<.001	<.001	3	9
GBM	ELANE →	+1.044	+0.093	<.001	<.001	3	9
GBM	MMP9 →	+1.536	+0.099	<.001	<.001	3	9
PDAC	PADI4 →	+0.929	+0.052	<.001	<.001	3	9
GBM	PRTN3 →	+0.954	+0.059	<.001	<.001	3	9
GBM	RETN →	+1.263	+0.086	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070498 vs UNC13D — GBM

Explore this scatter interactively →