Interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR223HG, PTAFR, and FGD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-1-mediated signaling pathway activity versus MIR223HG in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIR223HG →	+0.826	+0.190	.002	.005	3	7
LSCC	PTAFR →	+0.787	+0.303	<.001	.004	3	6
BRCA	FGD2 →	+0.680	+0.135	<.001	.006	3	6
LSCC	SIRPB2 →	+0.663	+0.314	.002	.004	3	6
BRCA	ITGAL →	+0.823	+0.162	.001	.001	3	6
BRCA	TRPV2 →	+0.788	+0.176	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070498 vs MIR223HG — LSCC

Explore this scatter interactively →