Thrombin-activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP2, BIN2, and SLAMF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thrombin-activated receptor signaling pathway activity versus IQGAP2 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IQGAP2 →	+1.083	+0.210	<.001	<.001	3	5
HNSC	BIN2 →	+0.799	+0.146	.002	<.001	3	5
GBM	SLAMF6 →	+0.572	+0.118	.003	.005	3	5
GBM	PTPRC →	+0.558	+0.136	.008	.002	3	5
GBM	SRGN →	+0.881	+0.129	<.001	.002	3	4
UCEC	GIMAP4 →	+0.727	+0.144	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070493 vs IQGAP2 — BRCA

Explore this scatter interactively →