Thrombin-activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNCA, HPGD, and LINC00310, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNCA grouped by Thrombin-activated receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNCA →	-0.431	-1.591	.001	<.001	3	8
BLOOD_Leukemia	HPGD →	-0.277	-1.253	.001	<.001	3	8
SKIN	LINC00310 →	-0.248	-1.298	.001	<.001	3	6
CNS	DGKQ →	-0.205	-0.779	.004	.005	3	6
LUNG_SCLC	NDUFS1 →	+0.233	+1.283	.005	.005	3	5
LARGE_INTESTINE	F2RL3 →	-0.254	-1.270	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNCA by Thrombin-activated receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →