Thrombin-activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXB8, ZNF579, and ASB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXB8 grouped by Thrombin-activated receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HOXB8 →	+0.878	+0.970	.004	.002	3	5
LARGE_INTESTINE	ZNF579 →	+1.045	+1.147	<.001	<.001	3	5
LARGE_INTESTINE	ASB1 →	+0.576	+0.881	.005	.005	2	6
SOFT_TISSUE	CRTC1 →	+0.684	+0.940	.004	.005	3	5
URINARY_TRACT	FLCN →	+1.670	+1.767	.006	.006	3	4
URINARY_TRACT	ZNF865 →	+0.805	+1.325	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXB8 by Thrombin-activated receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →