Thrombin-activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU6F2, NR0B1, and B4GALT7, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POU6F2 grouped by Thrombin-activated receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POU6F2 →	+0.065	+0.424	.005	.006	2	2
BREAST	NR0B1 →	+0.105	+0.424	.002	.006	2	2
LUNG_NSCLC_LUAD	B4GALT7 →	+0.258	+1.764	<.001	.005	2	2
BLOOD_Leukemia	POLQ →	+0.286	+2.039	.007	<.001	3	1
BLOOD_Leukemia	PON1 →	-0.221	-1.981	.003	<.001	3	1
LARGE_INTESTINE	TAOK1 →	-0.140	-1.543	.002	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POU6F2 by Thrombin-activated receptor signaling pathway activity — BREAST

Explore this box plot interactively →