Thrombin-activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HYAL3, MICAL3, and IRAK3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thrombin-activated receptor signaling pathway activity versus HYAL3 in BLOOD_Leukemia (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HYAL3 →	+1.890	+1.362	<.001	<.001	3	3
LUNG_SCLC	MICAL3 →	+0.771	+1.500	<.001	.001	3	3
BLOOD_Leukemia	IRAK3 →	+2.065	+1.086	.005	.004	3	2
BLOOD_Leukemia	APOM →	-1.298	-1.798	<.001	<.001	3	2
STOMACH	NAA80 →	+1.340	+1.757	.001	.001	3	2
STOMACH	PABPC1L →	+1.580	+1.757	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070493 vs HYAL3 — BLOOD_Leukemia

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