Monocyte aggregation

Across TCGA pan-cancer cohorts, RNA activity of the Monocyte aggregation pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Monocyte aggregation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and MESO, show the opposite pattern, with higher activity associated with better survival.

THCA, STAD, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	II,III,IV	0.639	0.928	<.001	78	view →
STAD	DFS	Quartile	II,III,IV	0.576	0.740	.008	53	view →
DLBC	DFS	Tertile	II,III,IV	0.114	1.000	.005	45	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
MESO	DFS	Tertile	All	0.472	0.242	<.001	36	view →
KIRC	DFS	Median	III,IV	0.655	0.838	.002	31	view →
LUAD	DFS	Tertile	IV	0.120	0.698	.002	24	view →
UCEC	DFS	Tertile	All	0.548	0.705	.005	20	view →
SKCM	OS	Quartile	II,III,IV	0.647	0.789	.005	20	view →
ACC	DFS	Median	II,III,IV	0.377	0.679	.003	19	view →
CESC	OS	Quartile	IV	0.268	0.823	.003	18	view →
OV	DFS	Median	All	0.483	0.595	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0070487–THCA (DFS)

Open the THCA breakdown →