rRNA base methylation

Across TCGA patient cohorts, RNA activity of the rRNA base methylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODN, PSAT1, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA base methylation activity versus PODN in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PODN →	-1.345	-0.296	<.001	<.001	3	7
BRCA	PSAT1 →	+1.986	+0.277	<.001	<.001	3	6
OV	CNRIP1 →	-0.646	-0.132	.002	.005	3	6
BRCA	FRZB →	-1.530	-0.363	<.001	<.001	3	6
LUAD	ITGA8 →	-0.978	-0.407	<.001	<.001	3	6
LSCC	HROB →	+0.790	+0.254	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070475 vs PODN — BRCA

Explore this scatter interactively →