rRNA base methylation

Across TCGA cell cohorts, RNA activity of the rRNA base methylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR43, NOP2, and MYBBP1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA base methylation activity versus WDR43 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WDR43 →	+0.854	+0.301	.001	.002	3	5
PANCREAS	NOP2 →	+0.740	+0.687	.003	.005	3	5
BONE	MYBBP1A →	+0.949	+0.215	.007	.001	3	4
LARGE_INTESTINE	RNASEL →	-0.712	-0.223	.003	<.001	3	4
LUNG_SCLC	PHB2 →	+0.620	+0.203	.006	.001	2	5
OVARY	PIWIL4 →	-1.250	-0.294	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070475 vs WDR43 — LUNG_SCLC

Explore this scatter interactively →