Positive regulation of uterine smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of uterine smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPER1, TACR2, and ABAT, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of uterine smooth muscle contraction activity versus GPER1 in ACC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	GPER1 →	+1.618	+0.094	<.001	<.001	3	24
STAD	TACR2 →	+2.302	+0.119	<.001	<.001	3	20
SCLC	ABAT →	+2.521	+1.184	<.001	<.001	3	19
UCS	ADRA2B →	+1.394	+0.064	<.001	<.001	3	18
UCS	ATP1B2 →	+1.946	+0.056	<.001	.001	3	17
STAD	RAMP2 →	+0.833	+0.085	<.001	.005	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070474 vs GPER1 — ACC

Explore this scatter interactively →