Positive regulation of uterine smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of uterine smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOV, ANKRD22, and ADGRF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOV grouped by Positive regulation of uterine smooth muscle contraction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RHOV →	+2.637	+1.109	<.001	<.001	3	4
BREAST	ANKRD22 →	+1.459	+0.963	.001	<.001	3	4
URINARY_TRACT	ADGRF1 →	+4.520	+1.488	.005	<.001	2	5
BREAST	SPINT1 →	+2.450	+1.052	.008	<.001	3	4
BREAST	BOK →	-1.025	-0.952	.003	<.001	3	4
OVARY	LRRC1 →	+0.814	+0.720	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOV by Positive regulation of uterine smooth muscle contraction activity — BREAST

Explore this box plot interactively →