Positive regulation of uterine smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of uterine smooth muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP5, APRT, and LAMA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP5 grouped by Positive regulation of uterine smooth muscle contraction-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BMP5 →	+0.245	+1.426	.001	<.001	3	4
URINARY_TRACT	APRT →	-0.387	-2.285	.003	<.001	3	3
URINARY_TRACT	LAMA5 →	-0.084	-2.174	<.001	<.001	3	3
STOMACH	ANKRD33 →	+0.150	+1.111	<.001	.005	3	3
SOFT_TISSUE	KCNJ8 →	+0.224	+1.442	<.001	<.001	3	3
SOFT_TISSUE	GPR26 →	+0.109	+1.465	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP5 by Positive regulation of uterine smooth muscle contraction activity — SOFT_TISSUE

Explore this box plot interactively →