Oligodendrocyte progenitor proliferation

pathway activity — cross-omics
GO:0070444Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte progenitor proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BIN2_S259, LYN, and TUT7_S132, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCABIN2_S259 →+0.425+0.052.005.00735
BRCALYN →+0.439+0.058<.001.00135
PDACTUT7_S132 →+0.479+0.077<.001<.00135
LSCCCNPY4 →-0.279-0.070.002.00335
LSCCPIP4K2B →-0.248-0.100<.001<.00135
PDACNAV1_S672 →+0.391+0.079.002<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration