Oligodendrocyte progenitor proliferation

pathway activity — cross-omics
GO:0070444Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte progenitor proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRP2_S4463, C2, and ARL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECLRP2_S4463 →+3.039+1.249.001<.00134
UCECC2 →-0.455-0.687<.001<.00133
LSCCARL3 →-0.319-0.756<.001<.00133
OVSUZ12_S546 →+0.553+0.294<.001.00333
COADKANK2_S246 →-0.594-0.743<.001<.00133
OVMARK4 →+1.169+0.608<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration