Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and RCSD1_S351, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway activity versus RCSD1 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.666	+0.093	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.820	+0.150	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.830	+0.094	<.001	<.001	3	10
UCEC	RENBP →	+0.508	+0.077	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.940	+0.152	<.001	<.001	3	10
OV	SASH3 →	+0.591	+0.106	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070432 vs RCSD1 — OV

Explore this scatter interactively →