Nucleotide-binding oligomerization domain containing 2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 2 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RIN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-binding oligomerization domain containing 2 signaling pathway activity versus RCSD1 in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.571	+0.107	<.001	<.001	3	10
BRCA	RCSD1_S351 →	+0.644	+0.055	<.001	<.001	3	10
HNSC	RIN3 →	+0.525	+0.094	<.001	<.001	3	10
OV	SASH3 →	+0.618	+0.085	<.001	<.001	3	10
GBM	SKAP2 →	+0.756	+0.111	<.001	<.001	3	10
HNSC	STK10 →	+0.538	+0.097	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070431 vs RCSD1 — GBM

Explore this scatter interactively →