Nucleotide-binding oligomerization domain containing 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK2, INAVA, and SLC37A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-binding oligomerization domain containing 2 signaling pathway activity versus RIPK2 in PANCREAS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RIPK2 →	+0.828	+0.109	<.001	<.001	3	10
LIVER	INAVA →	+2.969	+0.134	<.001	.002	3	7
URINARY_TRACT	SLC37A1 →	+1.759	+0.146	.009	.002	3	7
URINARY_TRACT	TMEM267 →	+0.914	+0.152	.001	.004	2	7
OESOPHAGUS	ELF3 →	+2.858	+0.104	<.001	<.001	3	6
BLOOD_Lymphoma	SYNGR2 →	+1.474	+0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070431 vs RIPK2 — PANCREAS

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