Nucleotide-binding oligomerization domain containing 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASEH2C, ABLIM3, and SCAF8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-binding oligomerization domain containing 2 signaling pathway activity versus RNASEH2C in OVARY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNASEH2C →	+0.924	+0.367	.007	.008	3	6
LIVER	ABLIM3 →	-3.298	-0.670	.006	.001	3	4
LUNG_SCLC	SCAF8 →	+0.652	+0.258	.001	<.001	3	4
LUNG_SCLC	PICALM →	+0.760	+0.257	.001	<.001	3	4
LUNG_SCLC	REV3L →	+0.963	+0.270	<.001	<.001	3	4
LUNG_SCLC	ZNF184 →	+0.594	+0.263	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070431 vs RNASEH2C — OVARY

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