Nucleotide-binding oligomerization domain containing 1 signaling pathway

pathway activity — cross-omics
GO:0070427Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 1 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, TBC1D2B, and DPYD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-binding oligomerization domain containing 1 signaling pathway activity versus STAB1 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSTAB1 →+0.512+0.082<.001<.00139
GBMTBC1D2B →+0.400+0.112<.001<.00139
GBMDPYD →+0.775+0.082<.001<.00139
LSCCANKRD44 →+0.461+0.093<.001<.00139
GBMLCP1 →+0.854+0.114<.001<.00139
BRCAWIPF1 →+0.418+0.054<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070427 vs STAB1 — GBM

Per-sample scatter of Nucleotide-binding oligomerization domain containing 1 signaling pathway activity vs STAB1 in GBM.

Explore this scatter interactively →

Exploration