Nucleotide-binding oligomerization domain containing 1 signaling pathway

Across TCGA patient cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 1 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICB, COLEC11, and ZNF804A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-binding oligomerization domain containing 1 signaling pathway activity versus MICB in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MICB →	+0.543	+0.450	<.001	.001	3	4
LUAD	COLEC11 →	-0.735	-0.487	<.001	.001	3	4
CCRCC	ZNF804A →	+0.294	+0.613	<.001	.002	3	4
CCRCC	TIE1 →	-0.828	-0.483	<.001	<.001	3	4
HNSC	SMOX →	-0.720	-0.236	<.001	.004	3	3
LUAD	PSME2 →	+0.547	+0.432	<.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070427 vs MICB — LSCC

Explore this scatter interactively →