"Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, CSF2RB, and TLR2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus TNFAIP3 in DLBC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TNFAIP3 →	+1.561	+0.094	<.001	<.001	3	33
TGCT	CSF2RB →	+1.661	+0.090	<.001	<.001	3	31
LGG	TLR2 →	+1.426	+0.065	<.001	<.001	3	31
SKCM	RGS18 →	+0.952	+0.082	<.001	<.001	3	31
BRCA	IL7R →	+1.822	+0.076	<.001	<.001	3	31
TGCT	EVI2B →	+1.798	+0.084	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070424 vs TNFAIP3 — DLBC

Explore this scatter interactively →