"Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF2, DEFB4A, and KATNBL1P5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus BATF2 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BATF2 →	+0.848	+0.441	.002	.007	3	3
LUAD	DEFB4A →	+0.807	+0.435	.001	<.001	3	3
UCEC	KATNBL1P5 →	-0.588	-0.719	<.001	.001	3	3
COAD	TRPC4 →	-0.236	-0.553	.003	<.001	3	3
CCRCC	NOVA2 →	-0.434	-0.665	.003	<.001	3	3
BRCA	EPAS1 →	-0.639	-0.507	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070424 vs BATF2 — OV

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