"Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLSPN, CCNYL1, and PLCG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLSPN grouped by "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLSPN →	-0.488	-0.318	.004	.008	3	3
LIVER	CCNYL1 →	-0.150	-1.891	.005	<.001	3	3
LUNG_SCLC	PLCG1 →	+0.275	+0.407	<.001	<.001	3	3
CNS	SDR9C7 →	+0.302	+1.460	.002	<.001	3	3
CNS	OR7A5 →	+0.377	+1.654	.006	<.001	3	3
LUNG_NSCLC_LUAD	ANKRD34B →	+0.294	+0.231	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLSPN by "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity — SKIN

Explore this box plot interactively →