"Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, PIP4K2A, and IFT172, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus NAGK in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NAGK →	+1.173	+0.786	<.001	.004	3	4
BLOOD_Lymphoma	PIP4K2A →	+1.367	+0.840	<.001	.002	2	4
LIVER	IFT172 →	+1.147	+1.919	<.001	<.001	3	3
LIVER	UBLCP1 →	+0.735	+1.919	.002	<.001	3	3
LIVER	DIPK1B →	-3.223	-1.919	.001	<.001	3	3
LIVER	NABP1 →	+1.746	+1.919	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070424 vs NAGK — BLOOD_Lymphoma

Explore this scatter interactively →