Cellular response to cold

Across TCGA cell cohorts, RNA activity of the Cellular response to cold pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPPED1, FOXI3, and TNFAIP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPPED1 grouped by Cellular response to cold-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MPPED1 →	-0.316	-1.892	.004	<.001	3	3
SOFT_TISSUE	FOXI3 →	-0.340	-1.619	.007	.007	3	3
BREAST	TNFAIP3 →	+0.187	+0.996	.003	.003	3	3
BREAST	TMEM42 →	-0.363	-1.269	.002	<.001	3	3
BLOOD_Myeloma	KCND3 →	+0.242	+0.358	.004	.002	2	4
UPPER_AERODIGESTIVE_TRACT	KCTD3 →	+0.137	+0.253	.007	.007	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPPED1 by Cellular response to cold activity — BLOOD_Leukemia

Explore this box plot interactively →