Cellular response to cold

Across TCGA cell cohorts, RNA activity of the Cellular response to cold pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC3, PLBD1, and TGDS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cold activity versus DNAJC3 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNAJC3 →	+1.265	+1.117	.001	.002	3	4
LUNG_NSCLC_LUAD	PLBD1 →	-2.300	-0.696	.001	.006	3	4
LUNG_NSCLC_LUAD	TGDS →	+1.097	+1.245	.003	<.001	3	3
BLOOD_Leukemia	SEC23B →	+0.547	+0.680	.002	.006	3	3
LUNG_NSCLC_LUAD	IL7 →	+1.110	+0.995	.004	.001	3	3
LUNG_NSCLC_LUAD	ST8SIA4 →	+1.447	+1.105	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070417 vs DNAJC3 — BLOOD_Lymphoma

Explore this scatter interactively →