DNA cytosine deamination

Across TCGA patient cohorts, RNA activity of the DNA cytosine deamination pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, VAV1, and GBP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA cytosine deamination activity versus IL2RB in OV (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL2RB →	+1.424	+0.827	<.001	.001	3	6
HNSC	VAV1 →	+0.609	+0.127	.002	<.001	3	6
OV	GBP5 →	+2.014	+0.870	<.001	.004	3	6
HNSC	LAPTM5 →	+0.817	+0.107	<.001	.001	3	6
BRCA	APOBEC3G →	+0.935	+0.897	<.001	<.001	3	6
BRCA	SPI1 →	+0.664	+0.794	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070383 vs IL2RB — OV

Explore this scatter interactively →