Positive regulation of ERK1 and ERK2 cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of ERK1 and ERK2 cascade pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, WAS, and WDFY4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERK1 and ERK2 cascade activity versus SASH3 in HNSC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SASH3 →	+0.469	+0.038	<.001	.003	3	10
OV	WAS →	+0.647	+0.055	<.001	<.001	3	10
LSCC	WDFY4 →	+0.488	+0.062	<.001	<.001	3	10
OV	AIF1 →	+0.801	+0.037	<.001	<.001	3	10
HNSC	FNBP1 →	+0.428	+0.042	<.001	.002	3	10
LSCC	ARHGAP45 →	+0.523	+0.053	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070374 vs SASH3 — HNSC

Explore this scatter interactively →