Positive regulation of ERK1 and ERK2 cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of ERK1 and ERK2 cascade pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAZ2, TAF9, and CROCC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAZ2 grouped by Positive regulation of ERK1 and ERK2 cascade-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OAZ2 →	+0.735	+0.182	.002	.003	3	4
BLOOD_Leukemia	TAF9 →	-0.972	-0.198	.001	.006	3	4
LUNG_SCLC	CROCC →	+1.177	+0.145	.001	.005	3	4
PANCREAS	VDR →	-1.526	-0.156	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PLGRKT →	-1.348	-0.163	<.001	.005	3	3
BREAST	FBH1 →	+0.534	+0.134	.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAZ2 by Positive regulation of ERK1 and ERK2 cascade activity — LUNG_SCLC

Explore this box plot interactively →