Positive regulation of ERK1 and ERK2 cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of ERK1 and ERK2 cascade pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIF1L, CTSA, and QSOX1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERK1 and ERK2 cascade activity versus AIF1L in LIVER (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AIF1L →	-3.832	-0.335	.004	.005	3	7
PANCREAS	CTSA →	+0.946	+0.253	.001	<.001	3	7
LUNG_NSCLC_LUSC	QSOX1 →	+2.907	+0.286	<.001	.008	3	6
OESOPHAGUS	ATXN7L3B →	-0.655	-0.300	.008	.001	3	5
SOFT_TISSUE	CRB3 →	-0.294	-0.311	.004	.005	2	6
LUNG_NSCLC_LUSC	STX2 →	+1.511	+0.207	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070374 vs AIF1L — LIVER

Explore this scatter interactively →