Negative regulation of ERK1 and ERK2 cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERK1 and ERK2 cascade pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFF, PPP1R15A, and DUSP6, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERK1 and ERK2 cascade activity versus MAFF in BONE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAFF →	+1.994	+0.074	<.001	<.001	3	11
BONE	PPP1R15A →	+1.629	+0.058	<.001	.001	3	11
BREAST	DUSP6 →	+2.013	+0.067	<.001	<.001	3	10
BLOOD_Leukemia	SCML2 →	-0.955	-0.035	.003	.008	3	9
BLOOD_Leukemia	CD63 →	+0.797	+0.049	<.001	<.001	3	9
BREAST	SNRPE →	-0.816	-0.081	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070373 vs MAFF — BONE

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