Hepatocyte differentiation

Across TCGA patient cohorts, RNA activity of the Hepatocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, MCM4, and UNG_S23, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte differentiation activity versus SMC2 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.617	+0.085	<.001	<.001	3	8
PDAC	MCM4 →	+0.550	+0.067	<.001	<.001	3	8
LUAD	UNG_S23 →	+0.926	+0.104	<.001	<.001	3	8
LSCC	CDK1 →	+0.610	+0.070	<.001	<.001	3	8
LSCC	MCM2 →	+0.516	+0.057	<.001	<.001	3	8
OV	MCM3 →	+0.771	+0.042	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070365 vs SMC2 — LSCC

Explore this scatter interactively →