Hepatocyte differentiation

Across TCGA patient cohorts, RNA activity of the Hepatocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, LINC00538, and PROX1-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte differentiation activity versus PROX1 in LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PROX1 →	+1.195	+0.397	<.001	.002	3	3
GBM	LINC00538 →	+0.387	+0.629	.008	<.001	3	3
GBM	PROX1-AS1 →	+0.406	+0.574	.006	<.001	3	3
PDAC	PTCHD3P2 →	+0.591	+0.305	<.001	.001	3	3
BRCA	SESN2 →	-0.628	-0.614	.002	.004	3	3
LSCC	MTMR11 →	+0.460	+0.510	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070365 vs PROX1 — LUAD

Explore this scatter interactively →