Hepatocyte differentiation

Across TCGA cell cohorts, RNA activity of the Hepatocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCB1, ARID1A, and FYN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCB1 grouped by Hepatocyte differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMARCB1 →	-0.302	-0.426	<.001	<.001	3	6
PANCREAS	ARID1A →	-0.367	-1.116	<.001	.008	3	4
BLOOD_Lymphoma	FYN →	+0.415	+0.332	.004	.004	3	4
BLOOD_Lymphoma	PHC3 →	+0.362	+0.384	.007	.007	3	4
OVARY	PON3 →	+0.206	+1.084	.009	.006	3	3
LARGE_INTESTINE	SIRPA →	+0.152	+0.564	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCB1 by Hepatocyte differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →