Hepatocyte differentiation

Across TCGA cell cohorts, RNA activity of the Hepatocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDSUB1, AGXT2, and BZW2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDSUB1 grouped by Hepatocyte differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WDSUB1 →	+0.241	+0.142	.009	.001	3	5
LIVER	AGXT2 →	-0.175	-0.096	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	BZW2 →	-0.262	-0.142	.001	.001	3	4
PANCREAS	DROSHA →	+0.162	+0.104	.006	.002	3	3
PANCREAS	HOXD4 →	-0.165	-0.144	.003	<.001	3	3
PANCREAS	GPR88 →	+0.151	+0.134	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDSUB1 by Hepatocyte differentiation activity — STOMACH

Explore this box plot interactively →