Hepatocyte differentiation

Across TCGA cell cohorts, RNA activity of the Hepatocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSRNP2, CD274, and FAM83A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte differentiation activity versus CSRNP2 in STOMACH (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CSRNP2 →	-1.266	-0.337	<.001	<.001	3	4
OESOPHAGUS	CD274 →	+1.713	+0.333	<.001	.007	3	4
LUNG_NSCLC_LUAD	FAM83A →	+3.289	+0.332	.001	.001	3	4
LUNG_NSCLC_LUAD	FMNL3 →	-1.123	-0.263	.004	<.001	3	4
STOMACH	PFKM →	-1.673	-0.323	.005	<.001	3	4
BLOOD_Lymphoma	ZNF669 →	-1.492	-0.346	.007	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070365 vs CSRNP2 — STOMACH

Explore this scatter interactively →