Negative regulation of fat cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fat cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TK1, MCM2, and MCM2_S139, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fat cell proliferation activity versus TK1 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TK1 →	+0.440	+0.110	<.001	<.001	3	7
LUAD	MCM2 →	+0.583	+0.123	<.001	<.001	3	7
LUAD	MCM2_S139 →	+0.740	+0.124	<.001	<.001	3	7
LUAD	MCM3 →	+0.604	+0.126	<.001	<.001	3	7
LUAD	MCM4 →	+0.630	+0.128	<.001	<.001	3	7
LUAD	MCM5 →	+0.614	+0.128	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070345 vs TK1 — LUAD

Explore this scatter interactively →