Negative regulation of fat cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fat cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB2, PHF7, and GIMAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPHB2 grouped by Negative regulation of fat cell proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EPHB2 →	+1.440	+0.691	.006	.006	3	4
LUNG_NSCLC_LUSC	PHF7 →	-1.267	-0.501	<.001	<.001	3	3
PANCREAS	GIMAP2 →	+1.195	+0.608	.003	.007	3	3
LUNG_NSCLC_LUAD	REC8 →	+0.720	+0.614	.002	.001	3	3
LUNG_NSCLC_LUAD	ATG14 →	+0.647	+0.793	.001	<.001	3	3
LUNG_NSCLC_LUSC	ERO1A →	+1.380	+0.423	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPHB2 by Negative regulation of fat cell proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →