Fat cell proliferation

Across TCGA patient cohorts, RNA activity of the Fat cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM3, MCM5, and MCM4_T110, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat cell proliferation activity versus MCM3 in OV (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MCM3 →	+0.699	+0.056	.003	.005	3	7
LUAD	MCM5 →	+0.654	+0.061	<.001	<.001	3	7
GBM	MCM4_T110 →	+1.446	+0.093	<.001	<.001	3	7
GBM	KPNA2 →	+0.507	+0.085	<.001	<.001	3	7
GBM	PRIM2 →	+0.371	+0.071	.004	<.001	3	7
GBM	RFC2 →	+0.270	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070341 vs MCM3 — OV

Explore this scatter interactively →