Thyroid hormone transport

Across TCGA patient cohorts, RNA activity of the Thyroid hormone transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC7A8, HSPA6, and UIMC1_S677, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone transport activity versus SLC7A8 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC7A8 →	+1.005	+0.080	<.001	<.001	3	5
OV	HSPA6 →	+0.397	+0.067	.006	.009	3	4
HNSC	UIMC1_S677 →	-0.402	-0.087	<.001	.005	3	4
HNSC	BCLAF1_S397 →	-0.323	-0.081	.001	.003	3	4
GBM	ZNF609_S1313 →	-0.347	-0.077	.002	<.001	3	4
PDAC	OS9 →	+0.223	+0.081	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070327 vs SLC7A8 — LSCC

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