Thyroid hormone transport

Across TCGA cell cohorts, RNA activity of the Thyroid hormone transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM7, RBM41, and DDX6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOMM7 grouped by Thyroid hormone transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TOMM7 →	-0.866	-1.119	.001	.002	3	5
BLOOD_Leukemia	RBM41 →	+1.402	+1.217	.003	.004	3	4
BLOOD_Leukemia	DDX6 →	+0.955	+1.190	<.001	<.001	3	4
BLOOD_Leukemia	POLR3G →	+0.860	+0.798	.002	.007	3	4
BLOOD_Leukemia	MAPK1IP1L →	+0.742	+1.068	<.001	.002	3	4
BLOOD_Leukemia	ZBTB49 →	+0.455	+1.186	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOMM7 by Thyroid hormone transport activity — BLOOD_Leukemia

Explore this box plot interactively →