Thyroid hormone transport

Across TCGA cell cohorts, RNA activity of the Thyroid hormone transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and AGAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone transport activity versus SLC7A5 in OESOPHAGUS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC7A5 →	+2.231	+0.280	<.001	.005	3	10
OESOPHAGUS	SLC3A2 →	+1.693	+0.214	.004	.007	1	9
LUNG_SCLC	AGAP2 →	-1.292	-0.291	.005	.001	3	4
LARGE_INTESTINE	CAPN5 →	-2.171	-0.413	<.001	<.001	3	4
URINARY_TRACT	C15orf39 →	+2.163	+0.512	.003	.009	3	4
BLOOD_Leukemia	EPC1 →	-1.094	-0.386	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070327 vs SLC7A5 — OESOPHAGUS

Explore this scatter interactively →