Negative regulation of G0 to G1 transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of G0 to G1 transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF700, HSD17B14, and ZCCHC10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF700 grouped by Negative regulation of G0 to G1 transition-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF700 →	-0.691	-0.720	.001	.003	3	4
OVARY	HSD17B14 →	+2.327	+1.089	<.001	.002	3	3
OESOPHAGUS	ZCCHC10 →	-0.553	-0.878	.002	.003	3	3
URINARY_TRACT	RBM4B →	-0.679	-0.327	.002	.007	3	3
BLOOD_Lymphoma	EIF3F →	-0.867	-1.755	<.001	.006	3	3
LUNG_NSCLC_LUAD	CDKN1B →	-0.585	-0.815	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF700 by Negative regulation of G0 to G1 transition activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →