G1 to G0 transition involved in cell differentiation

Across TCGA patient cohorts, RNA activity of the G1 to G0 transition involved in cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12B, LARP7, and TP53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G1 to G0 transition involved in cell differentiation activity versus PPP1R12B in CCRCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP1R12B →	+0.586	+0.040	<.001	<.001	3	5
GBM	LARP7 →	-0.330	-0.079	<.001	<.001	3	5
OV	TP53 →	-0.799	-0.075	.009	.001	3	4
GBM	CCDC86 →	-0.302	-0.057	<.001	<.001	3	4
CCRCC	ADH1B →	+0.789	+0.048	<.001	<.001	3	4
COAD	APC_S2449 →	-0.389	-0.031	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070315 vs PPP1R12B — CCRCC

Explore this scatter interactively →