G1 to G0 transition involved in cell differentiation

Across TCGA patient cohorts, RNA activity of the G1 to G0 transition involved in cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT4EP, TCF19, and RMI2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G1 to G0 transition involved in cell differentiation activity versus MGAT4EP in HNSC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MGAT4EP →	-0.212	-0.502	.006	.003	3	4
LUAD	TCF19 →	-0.646	-0.261	<.001	<.001	3	3
LUAD	RMI2 →	-0.391	-0.163	.003	.007	2	4
LUAD	RAC1P2 →	-0.433	-0.247	.001	.001	3	3
CCRCC	GINS1 →	-0.383	-0.246	.001	.002	3	3
HNSC	MYOM1 →	+1.893	+0.792	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070315 vs MGAT4EP — HNSC

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