G1 to G0 transition

Across TCGA patient cohorts, RNA activity of the G1 to G0 transition pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, IRAG1, and JAM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G1 to G0 transition activity versus MEF2C in LSCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEF2C →	-0.563	-0.911	<.001	<.001	3	7
LSCC	IRAG1 →	-0.397	-0.549	.005	.003	3	7
UCEC	JAM3 →	-0.608	-0.714	<.001	<.001	3	6
BRCA	GASK1B →	-1.119	-0.571	<.001	<.001	3	6
UCEC	CLEC14A →	-0.567	-0.761	.005	<.001	3	6
BRCA	SYNC →	-0.657	-0.479	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070314 vs MEF2C — LSCC

Explore this scatter interactively →