G1 to G0 transition

Across TCGA cell cohorts, RNA activity of the G1 to G0 transition pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR45B, RTN4R, and FSCN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR45B grouped by G1 to G0 transition-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WDR45B →	-1.061	-1.089	.004	.008	3	4
PANCREAS	RTN4R →	-1.403	-0.992	<.001	.001	3	4
BLOOD_Leukemia	FSCN3 →	-0.168	-1.221	.004	.003	3	3
OVARY	FZD3 →	-0.686	-0.907	.001	.001	3	3
OVARY	N4BP3 →	-0.915	-0.936	<.001	<.001	3	3
OVARY	SFT2D2 →	-0.666	-1.096	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR45B by G1 to G0 transition activity — OESOPHAGUS

Explore this box plot interactively →