Lens fiber cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Lens fiber cell morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND1C_S582, GPSM3_S39, and ATL3_S535, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell morphogenesis activity versus DENND1C_S582 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DENND1C_S582 →	-0.700	-0.132	.002	.001	3	6
OV	GPSM3_S39 →	-0.559	-0.067	.007	.001	3	5
HNSC	ATL3_S535 →	-0.458	-0.076	<.001	<.001	3	5
COAD	ZMYM3_S464 →	+0.363	+0.065	<.001	<.001	3	5
HNSC	SMARCA1 →	+0.406	+0.075	.007	.001	3	5
CCRCC	SPIN1 →	+0.237	+0.051	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070309 vs DENND1C_S582 — GBM

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